ADAM10 Evens Out the Double-Edged Sword of Radiotherapy in Pancreatic Cancer

Abstract Radiotherapy plays an important role in the management of pancreatic ductal adenocarcinoma (PDAC), especially when patients are not surgical candidates. Radiation-induced tumor death provokes acute inflammation followed by a late-fibrotic response that parallels fibroinflammatory microenvironment PDAC, inciting question whether radiation-induced fibrosis contributes to PDAC progression. The study published this issue Mueller and colleagues presents potential mechanism linking with expression disintegrin metalloprotease 10 (ADAM10) ephrinB2, which may also contribute authors show ablation ADAM10 decreases improves survival preclinical models. These data suggest targeting help improve clinical outcomes radiotherapy, particularly if definitive radiation is possible. A better understanding biology radiotherapy cancer remains crucial, offer insight regard. See related article et al., p. 3255